In a near future, pollution has killed off the natural world and the population is forced to live underground. A woman attempts to smuggle a suitcase of contraband drug/chips from Los Angeles to the underground remnants of New York City, while eluding both police and gangsters. Along the way, she is aided by a romantic bio-mechanical android and pursued by Plughead, a villain with the ability to tap into people's minds.

References:
https://en.wikipedia.org/wiki/Circuitry_Man